Enhance your medical skills with our Doppler Ultrasound Course! Master blood flow assessment and vascular diagnosis with expert-led training, hands-on practice, and cutting-edge techniques. Enroll now to advance your career.
"
For students in Jaipur aiming to excel in the CUET, specialized coaching classes provide the guidance and support needed for competitive success. The best CUET classes in Jaipur focus on an in-depth curriculum, covering essential subjects with experienced faculty who understand the CUET pattern. These institutes offer comprehensive study materials, personalized mentoring, and mock tests to sharpen time management and exam techniques. With small batches and doubt-clearing sessions, students receive focused attention. The positive environment and strategic approach ensure students build confidence and maximize their potential for high scores in the CUET."
"
For students in Jaipur aiming to excel in the CUET, specialized coaching classes provide the guidance and support needed for competitive success. The best CUET classes in Jaipur focus on an in-depth curriculum, covering essential subjects with experienced faculty who understand the CUET pattern. These institutes offer comprehensive study materials, personalized mentoring, and mock tests to sharpen time management and exam techniques. With small batches and doubt-clearing sessions, students receive focused attention. The positive environment and strategic approach ensure students build confidence and maximize their potential for high scores in the CUET."
"
For students in Jaipur aiming to excel in the CUET, specialized coaching classes provide the guidance and support needed for competitive success. The best CUET classes in Jaipur focus on an in-depth curriculum, covering essential subjects with experienced faculty who understand the CUET pattern. These institutes offer comprehensive study materials, personalized mentoring, and mock tests to sharpen time management and exam techniques. With small batches and doubt-clearing sessions, students receive focused attention. The positive environment and strategic approach ensure students build confidence and maximize their potential for high scores in the CUET."
"
For students in Jaipur aiming to excel in the CUET, specialized coaching classes provide the guidance and support needed for competitive success. The best CUET classes in Jaipur focus on an in-depth curriculum, covering essential subjects with experienced faculty who understand the CUET pattern. These institutes offer comprehensive study materials, personalized mentoring, and mock tests to sharpen time management and exam techniques. With small batches and doubt-clearing sessions, students receive focused attention. The positive environment and strategic approach ensure students build confidence and maximize their potential for high scores in the CUET."
Kaizen Innovation is a dynamic and innovative company based in Jaipur, India. Known for its commitment to continuous improvement and cutting-edge solutions, Kaizen Innovation specializes in providing a wide range of services and products related to technology, software development, and digital transformation.
In terms of services, Kaizen Innovation offers a comprehensive range of IT solutions, including software development, mobile application development, web development, e-commerce solutions, and digital marketing services. The company adopts a client-centric approach, working closely with its clients to understand their requirements and provide customized solutions that drive business growth and success.
Kaizen Innovation is a unit of iKaizen Technocraft private limited Jaipur Rajasthan, Kaizen Innovation is provides best training and internship programs in jaipur for computer science, information technology, artificial intelligence, data science, python, java, full stack web development, electrical and electronics, plc, scada, panels designing, civil engineering, autocad, 3ds max, revit, staad pro, mechanical, autocad, solidworks, creo, catia, ansys, interior design, google sketchup, architecture design, graphic design, digital marketing, robotics, automations, video editing, animations, electric vehicles, solar panels, automobiles, etc.
Register now by clicking this link
https://kaizeninnovation.in/
Kaizen Innovation is a dynamic and innovative company based in Jaipur, India. Known for its commitment to continuous improvement and cutting-edge solutions, Kaizen Innovation specializes in providing a wide range of services and products related to technology, software development, and digital transformation.
In terms of services, Kaizen Innovation offers a comprehensive range of IT solutions, including software development, mobile application development, web development, e-commerce solutions, and digital marketing services. The company adopts a client-centric approach, working closely with its clients to understand their requirements and provide customized solutions that drive business growth and success.
Kaizen Innovation is a unit of iKaizen Technocraft private limited Jaipur Rajasthan, Kaizen Innovation is provides best training and internship programs in jaipur for computer science, information technology, artificial intelligence, data science, python, java, full stack web development, electrical and electronics, plc, scada, panels designing, civil engineering, autocad, 3ds max, revit, staad pro, mechanical, autocad, solidworks, creo, catia, ansys, interior design, google sketchup, architecture design, graphic design, digital marketing, robotics, automations, video editing, animations, electric vehicles, solar panels, automobiles, etc.
Register now by clicking this link
https://kaizeninnovation.in/
2024 Trend Updates: What Really Works In SEO & Content MarketingSearch Engine Journal
21 slides•617.8K views
The future of SEO is trending toward a more human-first and user-centric approach, powered by AI intelligence and collaboration. Are you ready?
Watch as we explore which SEO trends to prioritize to achieve sustainable growth and deliver reliable results. We’ll dive into best practices to adapt your strategy around industry-wide disruptions like SGE, how to navigate the top challenges SEO professionals are facing, and proven tactics for prioritizing quality and building trust.
You’ll hear:
- The top SEO trends to prioritize in 2024 to achieve long-term success.
- Predictions for SGE’s impact, and how to adapt.
- What E-E-A-T really means, and how to implement it holistically (hint: it’s never been more important).
With Zack Kadish and Alex Carchietta, we’ll show you which SEO trends to ignore and which to focus on, along with the solution to overcoming rapid, significant and disruptive Google algorithm updates.
If you’re looking to cut through the noise of constant SEO and content trends to drive success, you won’t want to miss this webinar.
Storytelling For The Web: Integrate Storytelling in your Design ProcessChiara Aliotta
39 slides•499.5K views
In this slides I explain how I have used storytelling techniques to elevate websites and brands and create memorable user experiences. You can discover practical tips as I showcase the elements of good storytelling and its applied to some examples of diverse brands/projects..
Classification of Selective Alpha Agonists Based on Generation
Selective alpha agonists can be classified into first-generation, second-generation, and third-generation based on their pharmacological properties, receptor specificity, and clinical applications.
1. First-Generation Selective Alpha Agonists
(Non-subtype selective, older agents, higher side effects)
These drugs act on α1 or α2 receptors but with lower specificity and more systemic side effects.
Selective α1 Agonists (Vasoconstrictors, Hypotension Treatment)
Methoxamine – Used to treat hypotension.
Phenylephrine – Used as a nasal decongestant and to increase blood pressure.
Midodrine – Used for orthostatic hypotension.
Metaraminol – Used in hypotensive states and shock.
Selective α2 Agonists (Centrally Acting, Anti-Hypertensive Drugs)
Clonidine – Used for hypertension, ADHD, and withdrawal syndromes.
Methyldopa – Used for hypertension, especially in pregnancy.
Guanfacine – Used in hypertension and ADHD.
2. Second-Generation Selective Alpha Agonists
(More receptor selectivity, improved safety profile, fewer side effects)
Selective α1 Agonists (Longer Duration, Specific Targeting)
Amidephrine – Used in hypotension.
Selective α2 Agonists (Better CNS Penetration, Neurological Uses)
Brimonidine – Used in glaucoma (reduces intraocular pressure).
Apraclonidine – Used in short-term treatment of glaucoma.
Tizanidine – Used as a muscle relaxant in spasticity.
Lofexidine – Used in opioid withdrawal treatment.
3. Third-Generation Selective Alpha Agonists
(Highly selective, fewer side effects, newer therapeutic applications)
Selective α2 Agonists (High Selectivity, Novel Applications)
Dexmedetomidine – Used as a sedative in ICU and anesthesia.
Medetomidine – Used in veterinary anesthesia.
Fadolmidine – Investigated for pain relief with fewer cardiovascular effects.
Detomidine – Used in veterinary medicine for sedation
Classification of Selective Beta Agonists Based on Generation
Selective β-adrenergic agonists can be classified into three generations based on their receptor selectivity, duration of action, and therapeutic advancements.
1. First-Generation Selective Beta Agonists
(Non-specific, Short-acting, Higher Side Effects)
Early β-agonists with partial selectivity, often affecting both β1 and β2 receptors.
Shorter duration of action, leading to frequent dosing requirements.
Key Drugs:
Isoproterenol – A non-selective β1 and β2 agonist, used for bradycardia and heart block.
Dobutamine – A selective β1 agonist, used in acute heart failure and cardiogenic shock.
Ritodrine – A selective β2 agonist, previously used for delaying preterm labor.
2. Second-Generation Selective Beta Agonists
(More Selective, Longer Duration, Improved Safety)
These drugs show improved selectivity for either β1 or β2 receptors, reducing unwanted cardiac effects.
Longer-acting compared to first-generation.
Selective β1 Agonists (Primarily Cardiac Stimulants)
Denopamine – Used in heart failure treatment.
Prenalte
echinocandins case presentation.dr ANKUSH GOYAL GMC PATIALADr Ankush goyal
10 slides•151 views
Echinocandins: A Comprehensive Overview
Introduction
Echinocandins are a class of antifungal agents that have gained significant prominence in the treatment of invasive fungal infections, particularly those caused by Candida and Aspergillus species. They are considered second-line or first-line treatment options in cases of azole-resistant fungal infections. This document provides an in-depth discussion of echinocandins, including their chemical structure, mechanism of action, pharmacokinetics, spectrum of activity, clinical applications, resistance mechanisms, adverse effects, and future perspectives.
Historical Background
Echinocandins were first discovered in the late 20th century when researchers were exploring natural antifungal compounds derived from fungi and other microorganisms. The first echinocandin, pneumocandin B0, was isolated from Glarea lozoyensis. Further modifications led to the development of caspofungin, micafungin, and anidulafungin, which are the three currently approved echinocandins for clinical use.
Chemical Structure
Echinocandins are cyclic lipopeptides composed of a large cyclic hexapeptide core linked to a long-chain fatty acid side group. This unique structure is crucial for their antifungal activity and their pharmacokinetic properties. The lipid tail enhances the compound's binding affinity to fungal cells, while the cyclic peptide core is responsible for inhibiting fungal cell wall synthesis.
Mechanism of Action
Echinocandins exert their antifungal effects by selectively inhibiting the enzyme (1→3)-β-D-glucan synthase, which is essential for the synthesis of β-glucan, a major component of the fungal cell wall. The inhibition of β-glucan synthesis results in cell wall weakening, osmotic instability, and ultimately fungal cell lysis. This mechanism makes echinocandins highly selective for fungi, as mammalian cells lack β-glucan.
Pharmacokinetics
Echinocandins are administered intravenously due to their poor oral bioavailability. The pharmacokinetic properties of caspofungin, micafungin, and anidulafungin vary slightly, but they share several common features:
Distribution: Echinocandins exhibit extensive tissue penetration, particularly in the liver, spleen, lungs, and kidneys. However, their penetration into the cerebrospinal fluid (CSF) is limited, making them less effective for central nervous system fungal infections.
Metabolism: Caspofungin undergoes hepatic metabolism through hydrolysis and N-acetylation, while micafungin is metabolized by the liver via arylsulfatase and catechol-O-methyltransferase. Anidulafungin undergoes spontaneous degradation in the plasma without significant hepatic metabolism.
Elimination: The elimination of echinocandins varies; caspofungin is excreted through both hepatic and renal routes, micafungin is eliminated hepatically, and anidulafungin is primarily excreted via fecal routes due to spontaneous degradation.
Half-life: Caspofungin has a half-life of approximately 9-
We all know that malaria is an infectious disease spread by mosquitos. Female Anopheles mosquitos spread the infection, a microorganism called a plasmodium, when taking a blood meal. But as the quotation often attributed to Mark Twain says “What gets us into trouble is not what we don’t know. It’s what we know for sure that just ain’t so”.
Like most residents of western Europe I thought little about Malaria until I had opportunity to travel to Africa. My destination in Southern Botswana was not on the malaria map. However, parts of the North of the country to which I intended to travel were. People told me I needed to get malaria tablets that had to be taken for a week or two in advance, then daily or weekly and for some time after leaving malaria areas. There were a few different medications and combination tablets available and I investigated which would be the lesser evil. None seemed particularly effective so I decided to check the evidence of the mosquito cause of malaria and how these tablets were supposed to act. I soon became suspicious of the complicated malaria transmission story.
I have written a book 'Malaria is Spread by Mosquitos?'.
This presentation is a short introduction to the topic. see https://usmalaria.com/
Chair, Eleonora Lad, MD, PhD, discusses geographic atrophy in this CME/COPE/IPCE activity titled “Improving the Patient Experience in Geographic Atrophy: Are You Putting the Latest Advances Into Practice?.” For the full presentation, downloadable Practice Aids, and complete CME/COPE/IPCE information, and to apply for credit, please visit us at https://bit.ly/49lZvbL. CME/COPE/IPCE credit will be available until March 20, 2026.
### **Acyclovir and Anti-Herpes Medications**
**Acyclovir** is an antiviral medication used to treat infections caused by herpes viruses, including:
- **Herpes simplex virus (HSV-1 & HSV-2)** – Causes cold sores and genital herpes.
- **Varicella-zoster virus (VZV)** – Causes chickenpox and shingles.
### **Mechanism of Action:**
Acyclovir works by inhibiting viral DNA replication. It is activated inside virus-infected cells, where it blocks viral enzymes, preventing the virus from multiplying.
### **Forms & Dosage:**
- **Oral (Tablets/Capsules/Liquid)** – Used for mild to moderate infections.
- **Topical (Cream/Ointment)** – For cold sores and mild skin infections.
- **Intravenous (IV)** – For severe infections like herpes encephalitis.
### **Other Anti-Herpes Medications:**
- **Valacyclovir (Valtrex)** – A prodrug of acyclovir with better absorption.
- **Famciclovir (Famvir)** – Another antiviral with a longer duration of action.
- **Penciclovir (Denavir)** – Used topically for herpes labialis (cold sores).
### **Uses:**
- Treats and manages outbreaks of herpes simplex.
- Reduces the severity and duration of symptoms.
- Used for long-term suppression to prevent recurrent infections.
- Helps in managing shingles and chickenpox.
### **Side Effects:**
- Nausea, vomiting, diarrhea.
- Headache, dizziness, fatigue.
- Rare: Kidney issues, allergic reactions.
### **Precautions:**
- Drink plenty of fluids to prevent kidney issues.
- Not a cure, but helps manage symptoms.
- Safe for most patients but should be used cautiously in people with kidney disease or weakened immune systems.
Good Laboratory Practices (GLP) Ensuring Quality and Compliance.pptxDr. Smita Kumbhar
53 slides•184 views
Good Laboratory Practices (GLP): Ensuring Quality and Compliance
Good Laboratory Practices (GLP) is a set of principles intended to ensure the quality, integrity, and reliability of non-clinical laboratory studies that support research and regulatory submissions. These guidelines are critical in the pharmaceutical, biotechnological, chemical, and environmental sectors, ensuring that laboratory-generated data are reproducible, credible, and internationally accepted.
GLP standards primarily apply to safety studies involving pharmaceuticals, pesticides, food additives, and industrial chemicals. Regulatory agencies, including the USFDA, EMA, and OECD, enforce GLP compliance to maintain scientific rigor and public safety.
USFDA GLP Regulations The U.S. Food and Drug Administration (USFDA) established Good Laboratory Practice regulations under 21 CFR Part 58. These regulations outline responsibilities for study directors, testing facilities, and personnel to maintain quality and integrity in non-clinical laboratory studies. The regulations cover various aspects, including study conduct, reporting, and archiving, ensuring consistency and accuracy in laboratory research.
Controlling the GLP Inspection Process
Regulatory authorities conduct inspections to verify GLP compliance. Laboratories must prepare for inspections by:
• Maintaining up-to-date documentation.
• Conducting internal audits.
• Ensuring personnel training and awareness.
• Implementing corrective actions for non-compliance.
Regulatory inspections typically assess laboratory infrastructure, personnel competence, study documentation, and adherence to protocols. Laboratories must demonstrate transparency and proactive quality control measures.
Documentation in GLP
Accurate and comprehensive documentation is crucial in GLP compliance. Key documentation elements include:
• Study protocols
• Standard operating procedures (SOPs)
• Raw data records
• Analytical reports
• Audit reports
• Equipment calibration records
• Archiving and retention policies
Proper documentation ensures traceability, accountability, and reliability in laboratory research.
Audit in GLP Compliance
Auditing is a critical component of GLP, ensuring adherence to established regulations and identifying areas for improvement. Audits can be internal (self-audit) or external (regulatory or third-party audits).
Goals of Laboratory Quality Audit
• Ensure compliance with GLP regulations.
• Identify gaps and areas for improvement.
• Validate data integrity and accuracy.
• Enhance operational efficiency.
• Prevent regulatory penalties and study disqualification.
Audit Tools in GLP
Laboratories use various audit tools to assess compliance, including:
• Checklists and self-assessments
• Internal quality audits
• Electronic data tracking systems
• Third-party inspections
• Root cause analysis
• Corrective and preventive action (CAPA) plans
Future of GLP Regulations
The integumentary system is the largest organ system of the human body, serving as the body's first line of defense against environmental hazards. It includes the skin, hair, nails, glands, and sensory receptors. This system plays a vital role in protection, thermoregulation, sensation, excretion, and vitamin D synthesis. Understanding its structure and function is crucial for comprehending how the body interacts with its surroundings.
Structure of the Integumentary System
The integumentary system comprises two main components:
The Skin (Cutaneous Membrane)
Accessory Structures (Hair, Nails, and Glands)
The Skin
The skin, also called the cutaneous membrane, consists of three primary layers:
1. Epidermis
The epidermis is the outermost layer of the skin, composed of stratified squamous epithelium. It lacks blood vessels and is primarily made of keratinocytes, which produce the protective protein keratin. Other important cells in the epidermis include:
Melanocytes – produce melanin, which protects against UV radiation.
Langerhans cells – involved in immune response.
Merkel cells – associated with sensory neurons for touch perception.
The epidermis has five distinct layers (from deep to superficial):
Stratum basale (germinativum) – contains basal cells responsible for generating new keratinocytes.
Stratum spinosum – provides structural integrity.
Stratum granulosum – where keratinization begins.
Stratum lucidum – found only in thick skin (palms and soles).
Stratum corneum – the outermost layer made of dead keratinized cells.
2. Dermis
The dermis is the thicker, connective tissue layer beneath the epidermis. It consists of collagen and elastic fibers, providing strength and flexibility. The dermis has two layers:
Papillary Layer – composed of loose areolar connective tissue; contains dermal papillae, capillaries, and sensory receptors.
Reticular Layer – made of dense irregular connective tissue; contains sweat glands, hair follicles, and blood vessels.
3. Hypodermis (Subcutaneous Layer)
The hypodermis is a layer of adipose and connective tissue that insulates the body, stores energy, and provides cushioning. It connects the skin to underlying muscles and bones.
Functions of the Integumentary System
The skin performs several essential functions, including:
1. Protection
The skin acts as a physical barrier against microorganisms, dehydration, UV radiation, and harmful chemicals. The acid mantle (low pH) of the skin inhibits bacterial growth.
2. Thermoregulation
The skin helps maintain body temperature through:
Sweating (eccrine and apocrine glands) – evaporative cooling.
Vasodilation – blood vessels widen to release heat.
Vasoconstriction – blood vessels narrow to retain heat.
Goosebumps (arrector pili muscles) – create an insulating layer.
3. Sensation
The skin contains specialized sensory receptors:
Meissner’s corpuscles – detect light touch.
Pacinian corpuscles – sense deep pressure and vibration.
Merkel cells –
PARKINSON’S USMLE style question by dr ankush goyalDr Ankush goyal
43 slides•234 views
Parkinsonism refers to a clinical syndrome characterized by a combination of motor and non-motor symptoms that resemble Parkinson’s disease (PD). It results from dysfunction in the basal ganglia, particularly due to dopamine deficiency in the substantia nigra.
Key Features of Parkinsonism:
1. Bradykinesia – Slowness of movement with difficulty in initiating and executing voluntary movements.
2. Rigidity – Increased muscle tone, presenting as either:
Lead-pipe rigidity (uniform resistance)
Cogwheel rigidity (intermittent resistance with a ratchet-like quality)
3. Tremor – Resting tremor, typically "pill-rolling" (4-6 Hz), that improves with movement.
4. Postural Instability – Impaired balance leading to a higher risk of falls.
Causes of Parkinsonism:
1. Idiopathic Parkinson’s Disease (PD) – The most common cause, due to progressive degeneration of dopaminergic neurons in the substantia nigra.
2. Drug-Induced Parkinsonism – Caused by dopamine-blocking agents (e.g., antipsychotics, metoclopramide, reserpine).
3. Atypical Parkinsonian Syndromes (Parkinson-plus syndromes) – Progressive conditions with additional features beyond classic Parkinsonism, such as:
Multiple System Atrophy (MSA)
Progressive Supranuclear Palsy (PSP)
Corticobasal Degeneration (CBD)
Dementia with Lewy Bodies (DLB)
4. Vascular Parkinsonism – Due to multiple small strokes affecting the basal ganglia.
5. Toxic or Metabolic Causes – Includes manganese poisoning, carbon monoxide exposure, Wilson’s disease.
6. Post-Encephalitic Parkinsonism – Rare, seen in survivors of encephalitis lethargica.
Diagnosis:
Clinical Evaluation – Based on cardinal motor symptoms.
Response to Levodopa – Helps differentiate PD from other causes.
Neuroimaging (MRI, DaTscan) – Useful in atypical cases.
Management:
Pharmacological Treatment:
Levodopa (with carbidopa)
Dopamine agonists (pramipexole, ropinirole)
MAO-B inhibitors (selegiline, rasagiline)
COMT inhibitors (entacapone)
Anticholinergics (for tremors)
Non-Pharmacological Treatment:
Physiotherapy, speech therapy
Deep Brain Stimulation (DBS) in selected cases
Let's Talk About It: Gynecologic Cancer (Calm Body, Calm Mind - Using Your Bo...RheannaRandazzo
14 slides•16 views
Stress manifests in our thinking, emotions, and bodies. Recognizing those signs and building skills to address stress takes attention and effort. Cultivating skills to use your body as a tool to help you find calm and regain a sense of control can help you navigate moments of heightened anxiety. Join us on Wednesday, March 12th, to learn strategies for quieting your body and, thereby, calming your mind. Let’s Talk About It.
These slides describe the role of genetic control in the regulation of cellular functions.
Learning Objectives:
1. Describe the structure of DNA
2. Recognise the different types of RNA
3. Briefly describe the steps of transcription to elucidate the functions of different types of RNA
4. Briefly describe the process of translation
5. Discuss the mechanisms of genetic control of cell functions
6. Describe the cell cycle
7. Briefly describe the process of DNA replication
8. Describe the control of cell reproduction by telomeres and telomerase
9. Compare and contrast apoptosis and necrosis
10. Explain the pathophysiology of cancer and ageing
This presentation by Thibault Schrepel, Associate Professor of Law at Vrije Universiteit Amsterdam University, was made during the discussion “Artificial Intelligence, Data and Competition” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/aicomp.
This presentation was uploaded with the author’s consent.
How to Leverage AI to Boost Employee Wellness - Lydia Di Francesco - SocialHR...SocialHRCamp
28 slides•153.2K views
Speaker: Lydia Di Francesco
In this workshop, participants will delve into the realm of AI and its profound potential to revolutionize employee wellness initiatives. From stress management to fostering work-life harmony, AI offers a myriad of innovative tools and strategies that can significantly enhance the wellbeing of employees in any organization. Attendees will learn how to effectively leverage AI technologies to cultivate a healthier, happier, and more productive workforce. Whether it's utilizing AI-powered chatbots for mental health support, implementing data analytics to identify internal, systemic risk factors, or deploying personalized wellness apps, this workshop will equip participants with actionable insights and best practices to harness the power of AI for boosting employee wellness. Join us and discover how AI can be a strategic partner towards a culture of wellbeing and resilience in the workplace.
Classification of Selective Alpha Agonists Based on Generation
Selective alpha agonists can be classified into first-generation, second-generation, and third-generation based on their pharmacological properties, receptor specificity, and clinical applications.
1. First-Generation Selective Alpha Agonists
(Non-subtype selective, older agents, higher side effects)
These drugs act on α1 or α2 receptors but with lower specificity and more systemic side effects.
Selective α1 Agonists (Vasoconstrictors, Hypotension Treatment)
Methoxamine – Used to treat hypotension.
Phenylephrine – Used as a nasal decongestant and to increase blood pressure.
Midodrine – Used for orthostatic hypotension.
Metaraminol – Used in hypotensive states and shock.
Selective α2 Agonists (Centrally Acting, Anti-Hypertensive Drugs)
Clonidine – Used for hypertension, ADHD, and withdrawal syndromes.
Methyldopa – Used for hypertension, especially in pregnancy.
Guanfacine – Used in hypertension and ADHD.
2. Second-Generation Selective Alpha Agonists
(More receptor selectivity, improved safety profile, fewer side effects)
Selective α1 Agonists (Longer Duration, Specific Targeting)
Amidephrine – Used in hypotension.
Selective α2 Agonists (Better CNS Penetration, Neurological Uses)
Brimonidine – Used in glaucoma (reduces intraocular pressure).
Apraclonidine – Used in short-term treatment of glaucoma.
Tizanidine – Used as a muscle relaxant in spasticity.
Lofexidine – Used in opioid withdrawal treatment.
3. Third-Generation Selective Alpha Agonists
(Highly selective, fewer side effects, newer therapeutic applications)
Selective α2 Agonists (High Selectivity, Novel Applications)
Dexmedetomidine – Used as a sedative in ICU and anesthesia.
Medetomidine – Used in veterinary anesthesia.
Fadolmidine – Investigated for pain relief with fewer cardiovascular effects.
Detomidine – Used in veterinary medicine for sedation
Classification of Selective Beta Agonists Based on Generation
Selective β-adrenergic agonists can be classified into three generations based on their receptor selectivity, duration of action, and therapeutic advancements.
1. First-Generation Selective Beta Agonists
(Non-specific, Short-acting, Higher Side Effects)
Early β-agonists with partial selectivity, often affecting both β1 and β2 receptors.
Shorter duration of action, leading to frequent dosing requirements.
Key Drugs:
Isoproterenol – A non-selective β1 and β2 agonist, used for bradycardia and heart block.
Dobutamine – A selective β1 agonist, used in acute heart failure and cardiogenic shock.
Ritodrine – A selective β2 agonist, previously used for delaying preterm labor.
2. Second-Generation Selective Beta Agonists
(More Selective, Longer Duration, Improved Safety)
These drugs show improved selectivity for either β1 or β2 receptors, reducing unwanted cardiac effects.
Longer-acting compared to first-generation.
Selective β1 Agonists (Primarily Cardiac Stimulants)
Denopamine – Used in heart failure treatment.
Prenalte
echinocandins case presentation.dr ANKUSH GOYAL GMC PATIALADr Ankush goyal
10 slides•151 views
Echinocandins: A Comprehensive Overview
Introduction
Echinocandins are a class of antifungal agents that have gained significant prominence in the treatment of invasive fungal infections, particularly those caused by Candida and Aspergillus species. They are considered second-line or first-line treatment options in cases of azole-resistant fungal infections. This document provides an in-depth discussion of echinocandins, including their chemical structure, mechanism of action, pharmacokinetics, spectrum of activity, clinical applications, resistance mechanisms, adverse effects, and future perspectives.
Historical Background
Echinocandins were first discovered in the late 20th century when researchers were exploring natural antifungal compounds derived from fungi and other microorganisms. The first echinocandin, pneumocandin B0, was isolated from Glarea lozoyensis. Further modifications led to the development of caspofungin, micafungin, and anidulafungin, which are the three currently approved echinocandins for clinical use.
Chemical Structure
Echinocandins are cyclic lipopeptides composed of a large cyclic hexapeptide core linked to a long-chain fatty acid side group. This unique structure is crucial for their antifungal activity and their pharmacokinetic properties. The lipid tail enhances the compound's binding affinity to fungal cells, while the cyclic peptide core is responsible for inhibiting fungal cell wall synthesis.
Mechanism of Action
Echinocandins exert their antifungal effects by selectively inhibiting the enzyme (1→3)-β-D-glucan synthase, which is essential for the synthesis of β-glucan, a major component of the fungal cell wall. The inhibition of β-glucan synthesis results in cell wall weakening, osmotic instability, and ultimately fungal cell lysis. This mechanism makes echinocandins highly selective for fungi, as mammalian cells lack β-glucan.
Pharmacokinetics
Echinocandins are administered intravenously due to their poor oral bioavailability. The pharmacokinetic properties of caspofungin, micafungin, and anidulafungin vary slightly, but they share several common features:
Distribution: Echinocandins exhibit extensive tissue penetration, particularly in the liver, spleen, lungs, and kidneys. However, their penetration into the cerebrospinal fluid (CSF) is limited, making them less effective for central nervous system fungal infections.
Metabolism: Caspofungin undergoes hepatic metabolism through hydrolysis and N-acetylation, while micafungin is metabolized by the liver via arylsulfatase and catechol-O-methyltransferase. Anidulafungin undergoes spontaneous degradation in the plasma without significant hepatic metabolism.
Elimination: The elimination of echinocandins varies; caspofungin is excreted through both hepatic and renal routes, micafungin is eliminated hepatically, and anidulafungin is primarily excreted via fecal routes due to spontaneous degradation.
Half-life: Caspofungin has a half-life of approximately 9-
We all know that malaria is an infectious disease spread by mosquitos. Female Anopheles mosquitos spread the infection, a microorganism called a plasmodium, when taking a blood meal. But as the quotation often attributed to Mark Twain says “What gets us into trouble is not what we don’t know. It’s what we know for sure that just ain’t so”.
Like most residents of western Europe I thought little about Malaria until I had opportunity to travel to Africa. My destination in Southern Botswana was not on the malaria map. However, parts of the North of the country to which I intended to travel were. People told me I needed to get malaria tablets that had to be taken for a week or two in advance, then daily or weekly and for some time after leaving malaria areas. There were a few different medications and combination tablets available and I investigated which would be the lesser evil. None seemed particularly effective so I decided to check the evidence of the mosquito cause of malaria and how these tablets were supposed to act. I soon became suspicious of the complicated malaria transmission story.
I have written a book 'Malaria is Spread by Mosquitos?'.
This presentation is a short introduction to the topic. see https://usmalaria.com/
Chair, Eleonora Lad, MD, PhD, discusses geographic atrophy in this CME/COPE/IPCE activity titled “Improving the Patient Experience in Geographic Atrophy: Are You Putting the Latest Advances Into Practice?.” For the full presentation, downloadable Practice Aids, and complete CME/COPE/IPCE information, and to apply for credit, please visit us at https://bit.ly/49lZvbL. CME/COPE/IPCE credit will be available until March 20, 2026.
### **Acyclovir and Anti-Herpes Medications**
**Acyclovir** is an antiviral medication used to treat infections caused by herpes viruses, including:
- **Herpes simplex virus (HSV-1 & HSV-2)** – Causes cold sores and genital herpes.
- **Varicella-zoster virus (VZV)** – Causes chickenpox and shingles.
### **Mechanism of Action:**
Acyclovir works by inhibiting viral DNA replication. It is activated inside virus-infected cells, where it blocks viral enzymes, preventing the virus from multiplying.
### **Forms & Dosage:**
- **Oral (Tablets/Capsules/Liquid)** – Used for mild to moderate infections.
- **Topical (Cream/Ointment)** – For cold sores and mild skin infections.
- **Intravenous (IV)** – For severe infections like herpes encephalitis.
### **Other Anti-Herpes Medications:**
- **Valacyclovir (Valtrex)** – A prodrug of acyclovir with better absorption.
- **Famciclovir (Famvir)** – Another antiviral with a longer duration of action.
- **Penciclovir (Denavir)** – Used topically for herpes labialis (cold sores).
### **Uses:**
- Treats and manages outbreaks of herpes simplex.
- Reduces the severity and duration of symptoms.
- Used for long-term suppression to prevent recurrent infections.
- Helps in managing shingles and chickenpox.
### **Side Effects:**
- Nausea, vomiting, diarrhea.
- Headache, dizziness, fatigue.
- Rare: Kidney issues, allergic reactions.
### **Precautions:**
- Drink plenty of fluids to prevent kidney issues.
- Not a cure, but helps manage symptoms.
- Safe for most patients but should be used cautiously in people with kidney disease or weakened immune systems.
Good Laboratory Practices (GLP) Ensuring Quality and Compliance.pptxDr. Smita Kumbhar
53 slides•184 views
Good Laboratory Practices (GLP): Ensuring Quality and Compliance
Good Laboratory Practices (GLP) is a set of principles intended to ensure the quality, integrity, and reliability of non-clinical laboratory studies that support research and regulatory submissions. These guidelines are critical in the pharmaceutical, biotechnological, chemical, and environmental sectors, ensuring that laboratory-generated data are reproducible, credible, and internationally accepted.
GLP standards primarily apply to safety studies involving pharmaceuticals, pesticides, food additives, and industrial chemicals. Regulatory agencies, including the USFDA, EMA, and OECD, enforce GLP compliance to maintain scientific rigor and public safety.
USFDA GLP Regulations The U.S. Food and Drug Administration (USFDA) established Good Laboratory Practice regulations under 21 CFR Part 58. These regulations outline responsibilities for study directors, testing facilities, and personnel to maintain quality and integrity in non-clinical laboratory studies. The regulations cover various aspects, including study conduct, reporting, and archiving, ensuring consistency and accuracy in laboratory research.
Controlling the GLP Inspection Process
Regulatory authorities conduct inspections to verify GLP compliance. Laboratories must prepare for inspections by:
• Maintaining up-to-date documentation.
• Conducting internal audits.
• Ensuring personnel training and awareness.
• Implementing corrective actions for non-compliance.
Regulatory inspections typically assess laboratory infrastructure, personnel competence, study documentation, and adherence to protocols. Laboratories must demonstrate transparency and proactive quality control measures.
Documentation in GLP
Accurate and comprehensive documentation is crucial in GLP compliance. Key documentation elements include:
• Study protocols
• Standard operating procedures (SOPs)
• Raw data records
• Analytical reports
• Audit reports
• Equipment calibration records
• Archiving and retention policies
Proper documentation ensures traceability, accountability, and reliability in laboratory research.
Audit in GLP Compliance
Auditing is a critical component of GLP, ensuring adherence to established regulations and identifying areas for improvement. Audits can be internal (self-audit) or external (regulatory or third-party audits).
Goals of Laboratory Quality Audit
• Ensure compliance with GLP regulations.
• Identify gaps and areas for improvement.
• Validate data integrity and accuracy.
• Enhance operational efficiency.
• Prevent regulatory penalties and study disqualification.
Audit Tools in GLP
Laboratories use various audit tools to assess compliance, including:
• Checklists and self-assessments
• Internal quality audits
• Electronic data tracking systems
• Third-party inspections
• Root cause analysis
• Corrective and preventive action (CAPA) plans
Future of GLP Regulations
The integumentary system is the largest organ system of the human body, serving as the body's first line of defense against environmental hazards. It includes the skin, hair, nails, glands, and sensory receptors. This system plays a vital role in protection, thermoregulation, sensation, excretion, and vitamin D synthesis. Understanding its structure and function is crucial for comprehending how the body interacts with its surroundings.
Structure of the Integumentary System
The integumentary system comprises two main components:
The Skin (Cutaneous Membrane)
Accessory Structures (Hair, Nails, and Glands)
The Skin
The skin, also called the cutaneous membrane, consists of three primary layers:
1. Epidermis
The epidermis is the outermost layer of the skin, composed of stratified squamous epithelium. It lacks blood vessels and is primarily made of keratinocytes, which produce the protective protein keratin. Other important cells in the epidermis include:
Melanocytes – produce melanin, which protects against UV radiation.
Langerhans cells – involved in immune response.
Merkel cells – associated with sensory neurons for touch perception.
The epidermis has five distinct layers (from deep to superficial):
Stratum basale (germinativum) – contains basal cells responsible for generating new keratinocytes.
Stratum spinosum – provides structural integrity.
Stratum granulosum – where keratinization begins.
Stratum lucidum – found only in thick skin (palms and soles).
Stratum corneum – the outermost layer made of dead keratinized cells.
2. Dermis
The dermis is the thicker, connective tissue layer beneath the epidermis. It consists of collagen and elastic fibers, providing strength and flexibility. The dermis has two layers:
Papillary Layer – composed of loose areolar connective tissue; contains dermal papillae, capillaries, and sensory receptors.
Reticular Layer – made of dense irregular connective tissue; contains sweat glands, hair follicles, and blood vessels.
3. Hypodermis (Subcutaneous Layer)
The hypodermis is a layer of adipose and connective tissue that insulates the body, stores energy, and provides cushioning. It connects the skin to underlying muscles and bones.
Functions of the Integumentary System
The skin performs several essential functions, including:
1. Protection
The skin acts as a physical barrier against microorganisms, dehydration, UV radiation, and harmful chemicals. The acid mantle (low pH) of the skin inhibits bacterial growth.
2. Thermoregulation
The skin helps maintain body temperature through:
Sweating (eccrine and apocrine glands) – evaporative cooling.
Vasodilation – blood vessels widen to release heat.
Vasoconstriction – blood vessels narrow to retain heat.
Goosebumps (arrector pili muscles) – create an insulating layer.
3. Sensation
The skin contains specialized sensory receptors:
Meissner’s corpuscles – detect light touch.
Pacinian corpuscles – sense deep pressure and vibration.
Merkel cells –
PARKINSON’S USMLE style question by dr ankush goyalDr Ankush goyal
43 slides•234 views
Parkinsonism refers to a clinical syndrome characterized by a combination of motor and non-motor symptoms that resemble Parkinson’s disease (PD). It results from dysfunction in the basal ganglia, particularly due to dopamine deficiency in the substantia nigra.
Key Features of Parkinsonism:
1. Bradykinesia – Slowness of movement with difficulty in initiating and executing voluntary movements.
2. Rigidity – Increased muscle tone, presenting as either:
Lead-pipe rigidity (uniform resistance)
Cogwheel rigidity (intermittent resistance with a ratchet-like quality)
3. Tremor – Resting tremor, typically "pill-rolling" (4-6 Hz), that improves with movement.
4. Postural Instability – Impaired balance leading to a higher risk of falls.
Causes of Parkinsonism:
1. Idiopathic Parkinson’s Disease (PD) – The most common cause, due to progressive degeneration of dopaminergic neurons in the substantia nigra.
2. Drug-Induced Parkinsonism – Caused by dopamine-blocking agents (e.g., antipsychotics, metoclopramide, reserpine).
3. Atypical Parkinsonian Syndromes (Parkinson-plus syndromes) – Progressive conditions with additional features beyond classic Parkinsonism, such as:
Multiple System Atrophy (MSA)
Progressive Supranuclear Palsy (PSP)
Corticobasal Degeneration (CBD)
Dementia with Lewy Bodies (DLB)
4. Vascular Parkinsonism – Due to multiple small strokes affecting the basal ganglia.
5. Toxic or Metabolic Causes – Includes manganese poisoning, carbon monoxide exposure, Wilson’s disease.
6. Post-Encephalitic Parkinsonism – Rare, seen in survivors of encephalitis lethargica.
Diagnosis:
Clinical Evaluation – Based on cardinal motor symptoms.
Response to Levodopa – Helps differentiate PD from other causes.
Neuroimaging (MRI, DaTscan) – Useful in atypical cases.
Management:
Pharmacological Treatment:
Levodopa (with carbidopa)
Dopamine agonists (pramipexole, ropinirole)
MAO-B inhibitors (selegiline, rasagiline)
COMT inhibitors (entacapone)
Anticholinergics (for tremors)
Non-Pharmacological Treatment:
Physiotherapy, speech therapy
Deep Brain Stimulation (DBS) in selected cases
Let's Talk About It: Gynecologic Cancer (Calm Body, Calm Mind - Using Your Bo...RheannaRandazzo
14 slides•16 views
Stress manifests in our thinking, emotions, and bodies. Recognizing those signs and building skills to address stress takes attention and effort. Cultivating skills to use your body as a tool to help you find calm and regain a sense of control can help you navigate moments of heightened anxiety. Join us on Wednesday, March 12th, to learn strategies for quieting your body and, thereby, calming your mind. Let’s Talk About It.
These slides describe the role of genetic control in the regulation of cellular functions.
Learning Objectives:
1. Describe the structure of DNA
2. Recognise the different types of RNA
3. Briefly describe the steps of transcription to elucidate the functions of different types of RNA
4. Briefly describe the process of translation
5. Discuss the mechanisms of genetic control of cell functions
6. Describe the cell cycle
7. Briefly describe the process of DNA replication
8. Describe the control of cell reproduction by telomeres and telomerase
9. Compare and contrast apoptosis and necrosis
10. Explain the pathophysiology of cancer and ageing
This presentation by Thibault Schrepel, Associate Professor of Law at Vrije Universiteit Amsterdam University, was made during the discussion “Artificial Intelligence, Data and Competition” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/aicomp.
This presentation was uploaded with the author’s consent.
How to Leverage AI to Boost Employee Wellness - Lydia Di Francesco - SocialHR...SocialHRCamp
Speaker: Lydia Di Francesco
In this workshop, participants will delve into the realm of AI and its profound potential to revolutionize employee wellness initiatives. From stress management to fostering work-life harmony, AI offers a myriad of innovative tools and strategies that can significantly enhance the wellbeing of employees in any organization. Attendees will learn how to effectively leverage AI technologies to cultivate a healthier, happier, and more productive workforce. Whether it's utilizing AI-powered chatbots for mental health support, implementing data analytics to identify internal, systemic risk factors, or deploying personalized wellness apps, this workshop will equip participants with actionable insights and best practices to harness the power of AI for boosting employee wellness. Join us and discover how AI can be a strategic partner towards a culture of wellbeing and resilience in the workplace.
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
Creative operations teams expect increased AI use in 2024. Currently, over half of tasks are not AI-enabled, but this is expected to decrease in the coming year. ChatGPT is the most popular AI tool currently. Business leaders are more actively exploring AI benefits than individual contributors. Most respondents do not believe AI will impact workforce size in 2024. However, some inhibitions still exist around AI accuracy and lack of understanding. Creatives primarily want to use AI to save time on mundane tasks and boost productivity.
Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.
PEPSICO Presentation to CAGNY Conference Feb 2024Neil Kimberley
PepsiCo provided a safe harbor statement noting that any forward-looking statements are based on currently available information and are subject to risks and uncertainties. It also provided information on non-GAAP measures and directing readers to its website for disclosure and reconciliation. The document then discussed PepsiCo's business overview, including that it is a global beverage and convenient food company with iconic brands, $91 billion in net revenue in 2023, and nearly $14 billion in core operating profit. It operates through a divisional structure with a focus on local consumers.
Content Methodology: A Best Practices Report (Webinar)contently
This document provides an overview of content methodology best practices. It defines content methodology as establishing objectives, KPIs, and a culture of continuous learning and iteration. An effective methodology focuses on connecting with audiences, creating optimal content, and optimizing processes. It also discusses why a methodology is needed due to the competitive landscape, proliferation of channels, and opportunities for improvement. Components of an effective methodology include defining objectives and KPIs, audience analysis, identifying opportunities, and evaluating resources. The document concludes with recommendations around creating a content plan, testing and optimizing content over 90 days.
How to Prepare For a Successful Job Search for 2024Albert Qian
The document provides guidance on preparing a job search for 2024. It discusses the state of the job market, focusing on growth in AI and healthcare but also continued layoffs. It recommends figuring out what you want to do by researching interests and skills, then conducting informational interviews. The job search should involve building a personal brand on LinkedIn, actively applying to jobs, tailoring resumes and interviews, maintaining job hunting as a habit, and continuing self-improvement. Once hired, the document advises setting new goals and keeping skills and networking active in case of future opportunities.
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
The document provides career advice for getting into the tech field, including:
- Doing projects and internships in college to build a portfolio.
- Learning about different roles and technologies through industry research.
- Contributing to open source projects to build experience and network.
- Developing a personal brand through a website and social media presence.
- Networking through events, communities, and finding a mentor.
- Practicing interviews through mock interviews and whiteboarding coding questions.
Google's Just Not That Into You: Understanding Core Updates & Search IntentLily Ray
1. Core updates from Google periodically change how its algorithms assess and rank websites and pages. This can impact rankings through shifts in user intent, site quality issues being caught up to, world events influencing queries, and overhauls to search like the E-A-T framework.
2. There are many possible user intents beyond just transactional, navigational and informational. Identifying intent shifts is important during core updates. Sites may need to optimize for new intents through different content types and sections.
3. Responding effectively to core updates requires analyzing "before and after" data to understand changes, identifying new intents or page types, and ensuring content matches appropriate intents across video, images, knowledge graphs and more.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
